Glucose-lowering Effect and Anti-inflammatory Activity of Aqueous Leaf Extract of Taraxacum officinale in Wistar Rats

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C Kitcher
J A Sarkodie
P Debrah
S Frimpong-Manso
E Oppong Bekoe
O Winston
G Akoto
C Hasford
I Asiedu-Gyekye
KBN Banga
AK Nyarko Kwadwo

Abstract

Background: The use of traditional medicine in treating and managing chronic diseases is currently a common practice. Taraxacum officinale (dandelion), commonly used as food, has been reported to have several pharmacological properties including blood glucose lowering effects in diabetes mellitus. In the present study, the hypoglycemic property of the leaves of T. officinale was investigated. Methods: The leaves of T. officinale were pulverized and extraction was done using distilled water. The extract was analysed for various classes of phytoconstituents. The antioxidant and anti-inflammatory effects were determined using 2, 2-diphenyl-1-picryhydrazyl (DPPH) and Carrageenan-induced foot edema respectively. The hypoglycemic effects of the extract were also studied in streptozotocin (STZ)-induced diabetic rats at three doses (10 mg/kg, 30 mg/kg and 60 mg/kg). Linear mixed model technique was used to analyze the multiple glucose measurements per rat. This model acknowledges the presence of dependency by introducing rat-specific random effect(s) which measures the individual rat variations either at baseline (random intercept) or at the different time point (random slope). Results: Saponins and polyphenols were found to be present in the extract. The linear mixed model estimated the overall trajectory of blood glucose levels. A random-intercept model was found to be sufficient to model the effect of treatment evolution. The results exhibited a dose-dependent decrease in the blood glucose levels of STZ-induced diabetic rats compared with the positive control (insulin treated group). Conclusion: The study has provided evidence that aqueous extract of T. officinale has hypoglycaemic property comparable to insulin over a period of time.

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How to Cite
1.
Kitcher C, Sarkodie J, Debrah P, Frimpong-Manso S, Oppong Bekoe E, Winston O, Akoto G, Hasford C, Asiedu-Gyekye I, Banga K, Kwadwo A. Glucose-lowering Effect and Anti-inflammatory Activity of Aqueous Leaf Extract of Taraxacum officinale in Wistar Rats. IJPPR [Internet]. 25Aug.2019 [cited 5Jul.2020];11(4):250-8. Available from: http://www.ijppr.com/index.php/IJPPR/article/view/1016
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Research Article