Anti-hyperglycaemic Activity of Tribulus terrestris Fruit Extract Restores Metabolic Imbalance in Letrozole Induced -PCOS Mice

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Amitabh Krishna
Parikha .
Poonam Singh

Abstract

Prevalence of obesity in women with PCOS varies from 50-80% and whether obesity leads to PCOS or vice versa is still a matter of debate. Thus, the aim of this study was to evaluate the efficacy of Tribulus terrestris on improving metabolic abnormalities associated with PCOS. PCOS was induced in mice by oral administration of letrozole for 21 days. PCOS induced mice treated with fruit extract of T. terrestris for 25 days restored body mass and showed a marked improvement in histo-morphological features of the ovary, pancreas and adipose tissue by decreasing expression of prohibitin, by decreasing serum glucose, insulin and lipid concentrations and by acting on key metabolic factors (pAKT, GLUT8 and IR). These findings also showed ameliorating effect of T. terrestris on insulin resistance as indicated by HOMA-IR and QUICKI values in the treated PCOS mice. Thus, the extract of T. terrestris might be considered as a potential therapeutic choice for a large majority of women dealing with PCOS.

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How to Cite
1.
Krishna A, . P, Singh P. Anti-hyperglycaemic Activity of Tribulus terrestris Fruit Extract Restores Metabolic Imbalance in Letrozole Induced -PCOS Mice. IJPPR [Internet]. 25Aug.2019 [cited 5Jul.2020];11(4):304-11. Available from: http://www.ijppr.com/index.php/IJPPR/article/view/1018
Section
Research Article